PhD thesis defense. Multidisciplinary approach to study HIF2a/PD-1 axes in clear cell renal cell carcinoma
2025-10-02 / Researchers
Clear cell renal cell carcinoma (ccRCC) is characterized by the inactivation of the Von Hippel-Lindau (VHL) tumour suppressor gene, leading to the stabilization and accumulation of hypoxia-inducible factor 2α (HIF2α) and constitutive activation of hypoxia
Clear cell renal cell carcinoma (ccRCC) is characterized by the inactivation of the Von Hippel-Lindau (VHL) tumour suppressor gene, leading to the stabilization and accumulation of hypoxia-inducible factor 2α (HIF2α) and constitutive activation of hypoxia-inducible pathways. This thesis aimed to investigate the role of HIF2α as a central driver of tumour progression, immune evasion and metabolic adaptation in ccRCC.
